Cardiology Division

Department of Medicine

University of California at

San Francisco Medical Center

CeNter for the StUdy of AdveRsiTy

and CardioascUlaR DiseasE

Nurture Center


(415) 502-3616

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Biological Allostasis

 Achieving “biological and  social fitness”


Achieving biopsychosocial      stability through change



Ability of the body to produce hormones and other substances that help an individual (s) adapt to predictable and unpredictable challenges.


The ability of the body to elicit physiological and behavioral changes that customize how individuals respond and cope with their unique experiences in a changing/stressful physical and social environment.



State of serious or persistent difficulty, calamity or misfortune.


Adversity is more than just one difficulty or setback. Adversity: a series of difficulties or misfortunes that keep you from achieving your goals and/or finding happiness.






















Lifelong Education

Individual: Combination of all formal and informal education that occurs through an individual’s lifespan to attain the fullest possible development in personal, social and professional life.


Continuous quest for a higher and better quality   of life.


Community: Process of continual improvement and growth by increasing knowledge or influencing attitudes.


The ability of a person to develop resilience, grow and thrive in the face of situational pressure and stressors, based on the combination of both their genotype/phenotype and the availability and maintenance of social resources developed over a lifetime.









































Achievement of participatory management that leads to the revealing of human potentials.



Dynamic process which leads an individual or community to acquiring decision-making power and control over their lives.


It involves changing others’ and self-perception of one’s competency and capacity through building knowledge, acquiring important skills and access to information and resources.























Process of adapting well in the face of adversity or significant sources of stress such as, trauma, tragedy, making use of a unique host of interacting biological, psychological, social and cultural factors.


Dynamic developmental process with attainment of positive adaptation